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Home » Knowledge Center » Endocrine Disrupting Chemicals (EDCs)

Knowledge Center

Endocrine Disrupting Chemicals (EDCs)

The endocrine system is a delicate and finely balanced system of hormones and glands. The endocrine system adjusts and regulates many bodily functions, including growth and development, sexual behavior, reproduction, stress control, metabolism, and production and use of insulin. Endocrine disruptors are chemicals – some natural, and others resulting from human activity (1).

 

There is strong scientific evidence that shows that exposure to EDCs interrupts the normal function of the reproductive system, and can lead to infertility, cancer in reproductive organs, and birth defects in the urinary system and sex organs. There is also a growing body of knowledge describing and analyzing the ways in which EDCs have a negative affect on other parts of the endocrine system, such as the thyroid gland and neuroendocrine system. These effects, in turn, cause learning disabilities, developmental problems, abnormal sexual development, diabetes, and obesity (2). The effects of EDCs have now reached epidemic proportions (1).

 

Until recently it was believed that EDCs present a risk only when one is exposed to high doses of chemicals, but recent evidence shows adverse affects occur even after low level exposures. Studies also suggest that EDCs’ influence depends on one's age at exposure and personal predisposition. Nonetheless, the riskiest time for exposure is in utero and as a newborn (3). For example, researchers have found that children of women who were exposed to phthalates during pregnancy had more disruptive behaviors. Phthalates are chemicals used in the plastic industry and can be found abundantly in everyday products such as bottles and cosmetics (4). Scientific literature also links exposure to phthalates to hypospadias (a congenital birth defect) and early development of breast buds in girls.

There is much evidence of endocrine disruption among wildlife as well. The main effects found among wildlife – both on land and in the water - were  effects on the function of the immune system, changes in sexual behavior and permanent effects on sex organ development (5).

 

 

Read More

  • NIEHS on EDCs
  • TEDX – The Endocrine Disruption Exchange

EDCs in Israel

To date, the links between EDCs and health in Israel have not been systematically examined. Hence, knowledge and data draw mainly from sporadic studies and surveys. The following studies provide some information.
 

  • Researchers have gathered data regarding the development of breast buds among 8 year-old girls. The study reviewed data from 1977 to 2002. The data suggest that this phenomenon is now 25 times more prevalent then it was in the past (6).
  • Another study shows that women in Israel born after 1978 were twice as likely to experience menarche by the age of 11 than women born before 1970 (7).
  • The number of both Jewish and Arab men diagnosed with testicular cancer has doubled between the years 1990-2006. There was also an overall increase in congenital malformations of the genital organs and urinary system among males between the years 2001-2006. In addition, there is evidence of changes in sperm quality, though data are sparse. One study examined sperm samples of men during fertility treatments, and found a decrease in sperm count and motility (8).
  • A pilot study that examined exposure of pregnant women to EDCs in Jerusalem found traces of phthalates in 95% of urine samples (levels similar to those found in the US). According to this study, personal care products were a source of one phthalate metabolite (9).
  • The Ministry of Heath has recently recommended avoiding the use of baby bottles containing bisphenol A due to the risk of this chemical mixing with the baby's food thus adversely affecting development (10).
  • Israel has restricted phthalate content of toys, and phthalate and BPA content in  food contact materials.

     

 

 

References
1) Endocrine Disruption Introduction. TEDX: The Endocrine Disruption Exchange. 2011. http://www.endocrinedisruption.com/endocrine.introduction.overview.php
2)
http://www.endo-society.org/journals/scientificstatements/
3) Endocrine Disruptors. National Institute of Environmental Health Sciences. 2010.
http://www.niehs.nih.gov/health/docs/endocrine-disruptors-2010.pdf
4) Wolff M. Phthalate Exposure Alters Children's Behavior and Cognitive Function. 2010.
http://www.niehs.nih.gov/research/supported/sep/2010/phthalate.cfm
5) Scientific Facts on Endocrine Disruptors. Green Facts: Facts on Health and the Environment.
http://www.greenfacts.org/en/endocrine-disruptors/l-2/endocrine-disrupto...
6) “Endocrine Disrupting Chemicals: A Symposium Held at the Faculty of Agricultural Sciences, Food, and Environmental Quality.” Israel Endocrine Society.2005.
http://www.ies.org.il/24072.asp
7) Chodick G, Huerta M, Balicer RD, Davidovitch N, Grotto I. Secular trends in age at menarche, smoking, and oral contraceptive use among Israeli girls. Prev Chronic Dis. 2005 Apr
http://www.cdc.gov/pcd/issues/2005/apr/04_0063.htm
8) Almagor M, Ivnitzki I, Yaffe H. 2003. Changes in semen quality in Jerusalem between 1990 and 2000: A cross- sectional and longitudinal study. Archives of Andrology 49:139-144.
9) Tamar Berman et al. Phthalate exposure among pregnant women in Jerusalem, Israel: results from a pilot study. Environment International. Environ Int. 35(2):353-7.  2008.

10) Ministry of Health Recommends Not to Use Baby Bottles Made from Polycarbonate Containing BPA. Israel Ministry of Health. 2011. http://www.health.gov.il/news/news.asp?ID=972

 

 

 

 

 

 

 

Links

EHF Activity: 
  •  Reproductive health and EDC's I EHF annual conference, 2009 
  • Monitoring of phthalates in pregnant women I Pilot research, 2008
  • Prof. Michele Marcus,reproduction and environment I Scholar in residents, 2009 
Additional info: 
  • Endocrine disruptors I American endocrine society scietific statement
  • Environmental Challenges to Reproductive Health I Summit proceedings, 2007 

 

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